Fig. 6: Raloxifene treatment reduces ADAM17 transcriptional levels increased by S exposure.

Effect of 48 hours treatment on modulation of ADAM17 mRNA in Calu-3 (A) and A549 (B) cell line treated with S protein (S 10 ng/ml), raloxifene (Raloxifene 20μΜ) and combined treatments (S 10 ng/ml + Raloxifene 20μΜ). Results are expressed as mean ± SD of 3 independent experiments. *p < 0.05, **p < 0.01, ***P < 0.001.