Fig. 3: ARIH2 is responsible for colony formation of GC cells in vitro and for tumor formation of GC cells in vivo. | Cell Death & Disease

Fig. 3: ARIH2 is responsible for colony formation of GC cells in vitro and for tumor formation of GC cells in vivo.

From: ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Fig. 3

A, B Soft agar assays of the control and ARIH2-knockdown MKN45 and SGC7901 cells were performed to detect the colony formation ability. Quantification of the number of cell clones. C–E Photographs, growth monitoring and weights of the indicated xenograft tumors. Data were analyzed using two-tailed Student’s t tests. F IHC analysis of ARIH2 and Ki67 expression was carried out in the indicated xenograft tumors. Scale bar = 50 μm. Quantification of ARIH2 and Ki67 expression. All data are expressed as the mean ± SD. Student’s t test was performed to analyze significance. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page