Fig. 1: LncRNA-mRNA co-expression networks in whole lung samples of IPF.

a IPF-related lncRNAs-mRNAs co-expression network in GSE24206. The diamond and round nodes are lncRNAs and mRNAs, respectively. Nodes marked with pink color represent the up-regulated IPF related genes. Nodes marked with blue color represent the down-regulated IPF-related genes. The size of nodes represents the degree and the line thickness of the edges indicates the strength of correlation. The solid lines (dotted lines) represent the positive (negative) correlation between mRNAs and lncRNAs (|r| > 0.8, P-value < 0.01, Pearson Correlation Test). b Distribution of the degree of genes in the IPF-related network (genes with degree greater than two were shown). TP53TG1 was the hub gene. c–f The expression of TP53TG1 in IPF compared to normal lung in four independent datasets (GSE24206, SRP108496, SRP033095 and SRP175341). *P-value < 0.05, **P-value < 0.01 in Student’s t-test. “ns”, no significance. g UMAP representation of 243,472 cells from 32 IPF and 28 normal donor lungs. Each dot represents a single cell, and cells are labeled as one of 39 discrete cell varieties. UMAP plot of all the single cells, with each color coded for (h) 60 patients, (i) sample origin (Normal or IPF). j Expression of TP53TG1.