Fig. 5: Effects of dexamethasone on the degeneration of outer hair cell in DC-targeted Cx26-null mice. | Cell Death & Disease

Fig. 5: Effects of dexamethasone on the degeneration of outer hair cell in DC-targeted Cx26-null mice.

From: The protective effects of systemic dexamethasone on sensory epithelial damage and hearing loss in targeted Cx26-null mice

Fig. 5

A Schematic of the experimental workflow, Cx26f/f; Fgfr3-CreER mice were injected with TMX and then treated with dexamethasone 5 mg /kg of body weight for five days. B–M Immunofluorescence staining with myosin 7a (red) and DAPI (blue) in different turns of the cochleae from different group. Representative images of the control group (B–D), control + DEX (E–G), Cx26 -null (H–J), and Cx26-null + DEX group (K–M) are shown. The White arrowheads in panels H–J indicate the miss of hair cells. N Quantification of the survival rate of OHCs in different treatment group. n = 5 mice in each group, ***P < 0.001. Scale in panel (B) represents for 40 μm.

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