Fig. 6: Ct-OATP1B3 enhances the mitochondrial FAO and OXPHOS activities and promotes lamellipodia formation in HGSOC cells. | Cell Death & Disease

Fig. 6: Ct-OATP1B3 enhances the mitochondrial FAO and OXPHOS activities and promotes lamellipodia formation in HGSOC cells.

From: Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation

Fig. 6

A Ct-OATP1B3 increases FAO oxidation rate in HGSOC cells. B–D Ct-OATP1B3 increases mitochondrial complex I activity (B), NAD+/NADP ratio (C), intracellular ATP level (D) in HGSOC cells. E, F Seahorse assays demonstrate that Ct-OATP1B3 promotes OCR in HGSOC cells. G Ct-OATP1B3 promotes the formation of lamellipodia in HGSOC cells. Lamellipodia extents at cell edges are quantified as a percentage of the cell circumference on 100 randomly selected cells in each group. Arrows indicate sites of lamellipodia extension. Scale bar, 10 μm. *P < 0.05, **P < 0.01, ***P < 0.001.

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