Table 1 The clinical characteristic and ASNS level in non-small cell lung-cancer patients (N = 92).

From: Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response

Characteristic

COX regression model

P*

HR(95%CI)

Age

(30–84 years)

0.781

1.079 (0.63,1.85)

 

30–50(9,10%)

  
 

50–70(61,66%)

  
 

70–84(23,24%)

  

Sex

male(49,53%)

0.524

1.202 (0.682,2.117)

 

female(43,47%)

  

Pathological degree

I–III

0.527

0.840 (0.491,1.44)

 

I(3,3%); II(61,66%);III(28,31%)

  

Tumor size

(1.5–14 cm)

0.416

1.183 (0.788,1.776)

 

1.5–3.0(18,20%)

  
 

3.0–4.5(45,49%)

  
 

≥4.5(29,31%)

  

lymph invasion

positive(58,63%)

0.806

0.897 (0.375,2.145)

 

negative(34,37%)

  

Clinical stages

I–IV

0.001

2.081 (1.343,3.224)

 

I(28,30%); II(17,18%);III(47,52,%)

  

ASNS expression**

cancer tissue (IHC score)

 

in nuclues

83%low(117 ± 57); 17%high(330 ± 77)

0.014

3.837 (1.313,11.214)

 

in cytoplasm

68%low(131 ± 33); 32%high(297 ± 60)

0.065

2.114 (0.954,4.683)

 

para-cancer tissue (IHC score)

 

in nuclues

65%low(92 ± 23); 35%high(180 ± 42)

0.686

1.262 (0.41,3.885)

 

in cytoplasm

60%low(77 ± 13); 40%high(124 ± 26)

0.237

0.473 (0.137,1.635)

  1. *P-value was calculated by COX regression model;
  2. **ASNS expression were detected by immunohistochemistry.
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