Fig. 6: Molecular model of FMRP-mediated regulation in GSCs. | Cell Death & Disease

Fig. 6: Molecular model of FMRP-mediated regulation in GSCs.

From: FMRP modulates the Wnt signalling pathway in glioblastoma

Fig. 6

FMRP is upregulated in GSCs and regulates the expression of WNT5B and CTNNB1 mRNAs, pivotal in stem cells maintenance. Increased levels of FMRP lead to the aberrant activation of the WNT canonical and non-canonical signalling pathways affecting the transcription of genes related to cell proliferation.

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