Fig. 2: High IDO1 expression predicted poor outcome, and IDO1 inhibition suppressed tumorigenesis in NOD/SCID mice. | Cell Death & Disease

Fig. 2: High IDO1 expression predicted poor outcome, and IDO1 inhibition suppressed tumorigenesis in NOD/SCID mice.

From: IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

Fig. 2

A Representative IHC images of IDO1 in normal tissue and 97 DLBCL patient samples (× 200, scale bar, 50 μm). B Kaplan-Meier OS analysis of DLBCL patients with high IDO1 expression and low IDO1 expression levels (P = 0.0204, n = 97). C and F A total of 5×106 OCI-Ly10 (C) or OCI-Ly3 (F) cells were subcutaneously injected into the posterior flank of NOD/SCID mice. Representative images of xenograft tumors treated with or without 1-L-MT are presented. D and G Tumor volume of OCI-Ly10 (D) or OCI-Ly3 (G) tumor-bearing mice demonstrated that the 1-L-MT-treated group presented a smaller size than the control group. E and H 1-L-MT-treated OCI-Ly10 (E) or OCI-Ly3 (H) tumor-bearing mice formed tumors with lower weights compared to the control group. Statistical analysis was analyzed with a two-sided student’s t-test. *P < 0.05 and **P < 0.01.

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