Fig. 5: MDM2 and TP53 were genes downstream of IDO1 in DLBCL. | Cell Death & Disease

Fig. 5: MDM2 and TP53 were genes downstream of IDO1 in DLBCL.

From: IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

Fig. 5

A The cluster heat map is classified as DEGs in IDO1 inhibition compared with Ctrl OCI-Ly10 cells. B–E Significantly enriched KEGG (B) and GO (C–E) pathway terms of the DEGs in IDO1 inhibition OCI-Ly10 cells were identified. F RT-qPCR was used to assess the mRNA levels of MDM2 in 1-L-MT and Ctrl OCI-Ly3/OCI-Ly10 cells. G RT-qPCR validation of TP53 mRNA levels in 1-L-MT and Ctrl OCI-Ly3/OCI-Ly10 cells. Statistical analysis was analyzed with a two-sided student’s t-test. *P < 0.05 and **P < 0.01.

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