Fig. 1: Enhanced autophagy and cisplatin resistance was observed in NSCLC cells under hypoxic conditions. | Cell Death & Disease

Fig. 1: Enhanced autophagy and cisplatin resistance was observed in NSCLC cells under hypoxic conditions.

From: Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance

Fig. 1

A CCK-8 assays suggesting that the viability of A549, HCC827, and NCI-H1299 cells treated with cisplatin increased after hypoxia exposure. B, C Western blotting indicating that LC3II/LC3I and HIF-1α levels increased and p62 levels decreased in three NSCLC cell lines (A549, HCC827, and NCI-H1299) under hypoxic conditions. D Staining for LC3 (green) and DAPI nuclear staining (blue) in A549 cells, showing that LC3II/LC3I expression increased in A549 cells under hypoxic conditions, and LC3 was located in the cytoplasm. *P < 0.05, **P < 0.01.

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