Fig. 1: SerpinB7 is abundantly expressed in epidermal keratinocytes. | Cell Death & Disease

Fig. 1: SerpinB7 is abundantly expressed in epidermal keratinocytes.

From: SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

Fig. 1

A Expression of SerpinB7 mRNA in normal (n = 15), non-lesional (n = 7), and lesional (n = 12) human psoriatic skin. B Correlation plot between SerpinB7 and IL-17a in human psoriatic lesion skin. C Immunoblot analysis of protein level of SerpinB7 in skin extracts from normal and psoriasis patients. β-actin was used as an internal control. D Immunohistochemistry staining of SerpinB7 in the skin from healthy and psoriasis patients, scale bar: overviews (100 μm) and insets (20 μm) (left), quantitative analysis of four fields per mouse (right), n = 5. E Expression of SerpinB7 mRNA of back skin from treated IMQ or control cream mice. F The SerpinB7 mRNA levels was measured by RT-PCR from dissected mice's epidermis and dermis. G Immunoblot analysis of protein level of SerpinB7 in skin extracts from normal and psoriasis patients. β-actin was used as an internal control. H Immunohistochemistry staining the skin from treated IMQ or control cream mice. scale bar: overviews (100 μm) and insets (20 μm) (left), quantitative analysis of four fields per mouse (right), n = 4. Mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. Two-tailed Student’s t-test (C–F and H), one-way ANOVA (A and G). All the data are representative of three independent experiments.

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