Fig. 2: SerpinB7 deficiency results in postnatal epidermal barrier defects and worsens psoriasis symptoms. | Cell Death & Disease

Fig. 2: SerpinB7 deficiency results in postnatal epidermal barrier defects and worsens psoriasis symptoms.

From: SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

Fig. 2

A Toluidine blue dye-penetration assay was performed with newborn SerpinB7+/+ and Serpinb7-/- mice indicating outside-in barrier defects. B SerpinB7+/+ and Serpinb7-/- mice CEs were isolated and treated with ultrasound for 120 min. CE destruction is indicated by the triangle. C Representative H&E staining section (20×) from the skin tissues of SerpinB7+/+ and Serpinb7-/- mice. Right: statistical analysis of skin epidermal thickness (mean ± SEM). D Representative immunohistochemical staining (20×) of Ki67 in the dorsal skin of SerpinB7+/+ and Serpinb7-/- mice. Right: quantification of Ki67-positive cells in the epidermis. E Representative Immunofluorescent staining of Krt10, Filaggrin, and Loricrin in the dorsal skin of SerpinB7+/+ and Serpinb7-/- mice.

Back to article page