Fig. 3: Ablation of SerpinB7 leads to exacerbation of IMQ-induced Psoriasis model. | Cell Death & Disease

Fig. 3: Ablation of SerpinB7 leads to exacerbation of IMQ-induced Psoriasis model.

From: SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

Fig. 3

A SerpinB7+/+ and SerpinB7-/- mice were treated with IMQ for 5 days, n = 5/group. Representative images of the dorsal skin from mice (left) and mice PASI scores were depicted (right). B Representative H&E staining section from the skin tissues of SerpinB7+/+ (n = 5) and SerpinB7-/- (n = 5) mice. Parakeratosis is indicated by the triangle, Munro’s microabscess is indicated by the arrows. Right: statistical analysis of skin epidermal thickness and inflammatory cell infiltration. C The RNA levels of keratinocytes differentiation-related genes were assessed by qPCR. D The RNA levels of chemokines and antimicrobial peptides were assessed by qPCR. E Immunofluorescent staining of Krt10, Filaggrin, and Loricrin in the dorsal skin of SerpinB7+/+ (n = 5) and Serpinb7-/- (n = 5) mice. Right: statistical analysis of staining intensity in the epidermis. Mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. Two-tailed Student’s t-test (A–E). All the data are representative of three independent experiments.

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