Fig. 7: Overexpression of EZH2 or lncRNA SNHG17 reversed the influences of LATS2 on PC9/GR and A549/GR cell migration, invasion and EMT. | Cell Death & Disease

Fig. 7: Overexpression of EZH2 or lncRNA SNHG17 reversed the influences of LATS2 on PC9/GR and A549/GR cell migration, invasion and EMT.

From: m6A methyltransferase METTL3-induced lncRNA SNHG17 promotes lung adenocarcinoma gefitinib resistance by epigenetically repressing LATS2 expression

Fig. 7

PC9/GR and A549/GR cells were transfected with LATS2 alone or in combination with EZH2 or lncRNA SNHG17. A, B Transwell chambers with/without Matrigel were used to estimate PC9/GR and A549/GR cell migration and invasion, respectively. C Western blot analysis of E-cadherin, N-cadherin, Vimentin and Snail in treated PC9/GR and A549/GR cells. D Immunofluorescence staining analysis of E-cadherin and N-cadherin in treated PC9/GR and A549/GR cells. Data were representative images or were expressed as the mean ± SD of n = 3 experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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