Fig. 3: Altered regulation of cell death in sepsis.
From: Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Severe infections can cause sepsis, and apoptosis, necrosis, necroptosis, pyroptosis, and autophagy, can be induced during sepsis. Altered regulation of cell death can lead to local inflammation, tissue injury, organ dysfunction, immunosuppressive pathophysiology, and multiple organ failure. Uncontrolled cell death can be manipulated to restore homeostasis.
