Table 1 Brief summary of necroptosis induced by common pathogens described in this review.
From: Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Pathogen | Research models | Identified virulence factors involved | Effects on host | References |
|---|---|---|---|---|
MCMV | Cell lines: NIH3T3 fibroblasts, 3T3-SA, SVEC4-10, MEFs, BMDMs; WT and transgenic mouse models | vICA, vMIA, M36, M45 | Protective | |
Influenza virus | Cell lines: BMDMs. Fibroblasts; WT and transgenic mouse models | NS1 | Protective, but detrimental at severe conditions. | |
Sendai virus | L929 | Y1, Y2 | Proposed protective | [137] |
Salmonella | Macrophages; WT and transgenic mouse models | K45A, SPI-2, NleB? | Detrimental | |
Mycobacterium | Fibroblasts, granulomas | ND | Detrimental | |
Helicobacter | AZ-521 | VacA | ND | [195] |
Pathogenic E. coli | 293 T cells, Hela cells | NleB | Protective | [61] |
Klebsiella pneumoniae | THP-1 cell line, WT, and transgenic mouse | ND | ND | [208] |
C. perfringens | Caco-2, Vero cells, human enterocyte-like T84 cell lines | Enterotoxin, β-toxin | ND | |
Leishmania | Bone marrow-derived macrophages | ND | Protective | [214] |
T. gondii | WT and transgenic mouse | ND | Proposed protective |
