Fig. 1: Thiostrepton reduces the viability and clonogenesis of pancreatic cancer cells.
From: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling
A Chemical structure of TST. B Panc-1, MIA PaCa-2, and BxPC-3 cells were treated with TST (0–200 μM) for 24 h, and cell viability was determined using the CCK-8 assay. C Western blotting analysis detected the level of the FOXM1 protein in different treatment groups (DMSO, 2 or 5 μM). D OD value of the CCK-8 assay conducted at 0, 24, 48, and 72 h using pancreatic cancer cells treated with different concentrations of TST (DMSO, 2, or 5 μM). E and F Panc-1, MIA PaCa-2, and BxPC-3 cells were treated with different doses of TST (DMSO, 2 or 5 μM), and cell clonogenesis was measured by using a colony formation assay (*P < 0.05 and **P < 0.01).
