Fig. 2: Thiostrepton promotes ferroptosis in pancreatic cancer cells.
From: Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling
A TEM imaging was conducted to control pancreatic cancer cells and TST (2 µM) treated pancreatic cancer cells. B OD value of the CCK-8 assay was conducted at 0, 24, 48, and 72 h using Panc-1, MIA PaCa-2, and BxPC-3 cells from different groups (DMSO, RSL3, TST, and TST + Fer-1). C and D The clonogenesis of pancreatic cancer cells in different treatment groups was measured using the colony formation assay. E ROS levels were detected in pancreatic cancer cells from different treatment groups with a ROS Assay Kit. F and G MDA and GSH-PX levels were detected in the different groups of treated Panc-1, MIA PaCa-2, and BxPC-3 cells. (*P < 0.05 and **P < 0.01).
