Fig. 3: SARM1PV-CKO male mice exhibited obvious anxiety-like behaviors.
From: SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice
A Schematic presentation of 2-month-old male SARM1f/f (left panel) and SARM1PV-CKO (right panel) mice in the OFT. B–D Quantitative analysis of total distance moved (B), time spent in center (C), and total activity time (D) in OFT involving SARM1f/f (n = 16) or SARM1PV-CKO mice (n = 17 animals) as shown in (A). E Schematic presentation of 2-month-old male SARM1f/f (left panel) and SARM1PV-CKO (right panel) mice in the elevated plus maze tests. F–H Quantitative analysis of time spent in open arms (F) or closed arms (G) or open arm entries (H) in elevated plus maze tests involving SARM1f/f (n = 16 animals) or SARM1PV-CKO mice (n = 17 animals). Quantitative data were analyzed using the Student’s t test and compared to the SARM1f/f group. ***p < 0.001.
