Fig. 6: Autism-like behaviors in SARM1PV-CKO mice may be due to the PVI dysfunction .
From: SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice
A Immunostaining of c-fos (green) in the brain of 2-month-old male SARM1f/f and SARM1PV-CKO mice. Cortex and hippocampus images are shown at a higher magnification. B Quantitative analysis of the number of c-fos+ cells in the cortex and hippocampus per mm2 as shown in (A) (n = 6 animals per group). C Western blot analysis of the expression of c-fos in the cortex and hippocampus of 2-month-old male SARM1f/f and SARM1PV-CKO mice. D Quantitative analysis of relative c-fos level as shown in (C) (n = 6 animals per group). E Western blot analysis of the expression levels of Neuronligin-1 and PSD-95 in the cortex and hippocampus of 2-month-old male SARM1f/f and SARM1PV-CKO mice. F Quantitative analysis of the Neuroligin-1 and PSD-95 relative expression level as shown in (E) (n = 6 animals per group). The density of the western blot bands was normalized with that of β-actin protein. Data are presented as the mean ± SEM. Quantitative data were analyzed using the Student’s t test and compared to the control group. *p < 0.05, **p < 0.01, ***p < 0.001. Scale bars, 1 mm.
