Fig. 4: AL101-induced tumor growth inhibition in vivo is associated with a decrease in NICD1, MYC, and Ki67 expression. | Cell Death & Disease

Fig. 4: AL101-induced tumor growth inhibition in vivo is associated with a decrease in NICD1, MYC, and Ki67 expression.

From: AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Fig. 4

Tumor sections derived from ACCx9 and ACCx11 (A) or ACCx5M1 and ACCx9 B xenograft model treated with either AL101 or vehicle were stained for NICD1, MYC, and Ki67 using an IHC. Representative images are shown. Act activated NOTCH1, WT wild-type NOTCH1.

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