Fig. 7: Schematic illustration depicting the role of NXN in suppressing tumor metastasis through promoting degradation of Snail. | Cell Death & Disease

Fig. 7: Schematic illustration depicting the role of NXN in suppressing tumor metastasis through promoting degradation of Snail.

From: NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3

Fig. 7

In normal liver cells, NXN promotes the ubiquitin-proteasome-mediated degradation of Snail. In HCC cells, the reduction of NXN decreases the interaction between NXN and DUB3 and results in the increased combination of Snail and DUB3. The increased interaction between DUB3 and Snail activates EMT and ultimately contributes to HCC metastases.

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