Table 2 Univariate and multivariate Cox regression analyses for overall survival in our cohort.

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
NXN (low/high)	2.126	1.479–3.055	<0.001*	1.963	1.348-2.859	<0.001*
Age (year) (≤50/>50)	0.867	0.605–1.243	0.438
Gender (male/female)	1.961	1.026–3.749	0.042*	1.932	0.990-3.733	0.053
HBsAg (yes/no)	0.839	0.451–1.560	0.578
ALB (g/L) (≤35/>35)	1.476	0.772–2.821	0.239
TBIL (μmol/L) (>17.1/≤17.1)	1.103	0.739–1.648	0.630
ALT (U/L) (>40/≤ 40)	1.789	1.248–2.564	0.002*	1.349	0.888–2.050	0.161
AST (U/L) (>45/≤ 45)	2.308	1.612–3.304	<0.001*	1.619	1.055–2.484	0.027*
AFP (ng/ml) (>400/≤400)	1.339	0.930–1.928	0.116
Tumor number (multiple/solitary)	2.012	1.339–3.022	0.001*	1.981	1.313–2.989	0.001*
Tumor size (cm) (>5/≤5)	1.529	1.065–2.194	0.021*	1.231	0.836–1.813	0.293
Tumor capsule (incomplete/complete)	1.209	0.663–2.205	0.536
Vascular invasion (yes/no)	1.138	0.790–1.640	0.488
Cirrhosis (yes/no)	0.963	0.875–1.061	0.449
TNM stage (III-IV/I-II)	2.919	1.761–4.841	<0.001*

HR hazard ratio, CI confidence interval, NXN expression in tumor nucleus, HBsAg hepatitis B surface antigen, ALB albumin, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate transaminase, AFP alpha-fetoprotein, TNM stage tumor-node-metastasis stage. *P < 0.05.

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