Fig. 7: Exosomes derived from HGG patients have variable effects on neuronal excitability and synchrony. | Cell Death & Disease

Fig. 7: Exosomes derived from HGG patients have variable effects on neuronal excitability and synchrony.

From: The dual action of glioma-derived exosomes on neuronal activity: synchronization and disruption of synchrony

Fig. 7

Network-wide and single-cell electrophysiological phenotype of neurons treated with exosomes from HGG patients (A: S471; B: S496). Raster plots from MEA recordings and correlation coefficients among spike times are shown in the upper panels, before (Ctr, black) and 24 h after exosome incubation (Exo, blue). The y axes on the raster plots represent channels’ numbers. The average correlation values across 10 channels were calculated and their distribution compared using Wilcoxon–Mann–Whitney U test; **p < 0.001, ****p < 0.0001; n = 12, average of 10 channels. In the lower panels, raster plots of single-cell neuronal activity are shown for neurons treated with patients’ exosomes and the respective controls. The distributions of firing rate (Hz) and resting membrane potentials (RMP) are shown; statistics were performed using the Wilcoxon–Mann–Whitney U test; **p < 0.001, ****p < 0.0001; n = 3/6 for S471, 4/9 for S496 (neurons analyzed in Ctr/Exo samples, respectively).

Back to article page