Fig. 2: Targeting CAMPs to attenuate inflammation and acute lung injury (ALI) in sepsis. | Cell Death & Disease

Fig. 2: Targeting CAMPs to attenuate inflammation and acute lung injury (ALI) in sepsis.

From: Chromatin-Associated Molecular Patterns (CAMPs) in sepsis

Fig. 2

Several inhibitors, i.e., neutralizing antibodies targeting CAMPs or their receptors, small molecule inhibitors, like C23 and M3, CI-Amidine, endogenous inhibitor like miRNAs, RNases, DNase, scavenging molecules, i.e., cNP, NABPs, MSR1 have been discovered to counteract CAMPs, thereby inhibiting the release of inflammatory mediators, cellular infiltrations, and differentiation and inhibit the development of ALI in sepsis. cfDNA Cell-free DNA, TERRA Telomeric repeat-containing RNA, eCIRP Extracellular CIRP, cNP Cationic nanoparticles, NABPs Nucleic acid-binding polymers, MSR1 Macrophage scavenger receptor 1.

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