Fig. 7: LINC00941 promotes PC growth and metastasis through upregulating ANXA2 and activating FAK/AKT signaling in vivo. | Cell Death & Disease

Fig. 7: LINC00941 promotes PC growth and metastasis through upregulating ANXA2 and activating FAK/AKT signaling in vivo.

From: LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2

Fig. 7

A The schematic diagram of the mouse model of cancer proliferation. B The photograph of tumors in empty vector group, lv-LINC00941 group, lv-LINC00941 + sh-ANXA2 group and lv-LINC00941 + PF-562271 (30 mg/kg/d) group (n = 4/per group). C The tumor volume in these groups. D The tumor weight in these groups. E IHC analysis was performed to evaluate the expression of proliferation markers, including Ki67 and PCNA, and grade malignancy using H&E staining. F The schematic diagram of the mouse model of cancer metastasis. G The living imaging of tumors in empty vector group, lv-LINC00941 group, lv-LINC00941 + sh-ANXA2 group and lv-LINC00941 + PF-562271 (30 mg/kg/d) group (n = 4/per group). H The liver metastases in these groups were stained with H&E. I The lung metastases in these groups were stained with H&E. J The statistical chart of liver or lung metastases. * and **, respectively, represent P < 0.05 and P < 0.01.

Back to article page