Fig. 8: The schematic diagram of LINC00941 promoting pancreatic cancer progression. | Cell Death & Disease

Fig. 8: The schematic diagram of LINC00941 promoting pancreatic cancer progression.

From: LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2

Fig. 8

LINC00941 acts as a decoy to interact with ANXA2, blocking the key interaction domain between NEDD4L and ANXA2, inhibiting ubiquitin-mediated degradation of ANXA2. Eventually, LINC00941 stabilizes ANXA2 and promotes activation of FAK/AKT signaling, resulting in facilitating pancreatic cancer proliferation, migration, and invasion (the figure was drawn by Figdraw, ID:UPATW888a4).

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