Fig. 3: Overexpression of lncRNA HEPFAL promotes cell ferroptosis. | Cell Death & Disease

Fig. 3: Overexpression of lncRNA HEPFAL promotes cell ferroptosis.

From: LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination

Fig. 3

A FACS and statistical analysis of ROS level in HCCLM3 and PLC cells stably overexpressing lncRNA HEPFAL. B, C Intracellular GSH levels were examined in HCCLM3 and PLC cells treated as indicated, and bar graphs are shown. D HCCLM3 and PLC cells stably overexpressing lncRNA HEPFAL were subjected to transmission electron microscopy. Representative images are shown. E Western blot analysis of NRF2, ACSL4, SLC7A11, FSP1 and GPX4 protein level in HCCLM3 and PLC cells transfected with lncRNA HEPFAL expression vector and control vector. *P < 0.05, **P < 0.01, ***P < 0.001.

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