Fig. 5: SLC7A11 rescued ferroptosis caused by the overexpression of lncRNA HEPFAL. | Cell Death & Disease

Fig. 5: SLC7A11 rescued ferroptosis caused by the overexpression of lncRNA HEPFAL.

From: LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination

Fig. 5

A HCCLM3 and PLC cell migration capacities were conducted by wound healing assays after transfected. B Cell migration and invasion abilities were indicated by transwell assays in each group. C, D ROS level was detected by FACS in HCCLM3 and PLC cells transfected as indicated. E, F Intracellular GSH levels were examined in HCCLM3 and PLC cells transfected as indicated. G FACS assessed intracellular Fe2+ ions generation in HCCLM3 and PLC cells transfected as indicated. H Western blot analysis of NRF2, ACSL4, SLC7A11, FSP1, and GPX4 protein levels in HCCLM3 and PLC cells transfected as indicated. ns is not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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