Fig. 4: A1 deletion increases pathological neovascularization and decreases vascular repair at P17. | Cell Death & Disease

Fig. 4: A1 deletion increases pathological neovascularization and decreases vascular repair at P17.

From: Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair

Fig. 4

A–C WT and A1 KO littermates were subjected to OIR at P7 and prepared for analysis on P17. Avascular area (AVA, yellow outline) and pathological RNV (tufts, highlighted in white) were significantly increased in A1 KO retinas. Scale bar = 100 µm. D, E Higher magnification images show decreased vessel sprouts at the AVA border zone of the P17 lectin-labeled A1 KO retina flatmounts. Scale bar = 20 µm. F, G Fluorescein angiography images show persistent vessel tortuosity in the WT OIR retinas through P50, which was increased in the A1 KO retinas. Data are presented as mean ± SD in all the figures.

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