Fig. 4: The activation of the IGF1/IGF1R-related signaling pathways by GASP1 in breast cancer cells. | Cell Death & Disease

Fig. 4: The activation of the IGF1/IGF1R-related signaling pathways by GASP1 in breast cancer cells.

From: GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway

Fig. 4

a The potential downstream pathways of GASP1 were identified by FunRich. b The effect of GASP1 overexpression on the activities of multiple signaling pathways, including IGF1/IGF1R1, NF-κB, PI3K/AKT, and MAPK/ERK pathways. GAPDH was used as a loading control. c The effect of GASP1 knockout on the activities of IGF1/IGF1R1, NF-κB, PI3K/AKT, and MAPK/ERK pathways. d Representative tumor sections from GASP1-knockout and control mice were subjected to IHC staining with the indicated antibodies. Scale bar, 200 µm. Data were presented as mean ± SD. **P < 0.01; ***P < 0.001.

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