Fig. 7: The potential regulatory mechanism of inhibiting autophagy to enhance the cytotoxicity of FIIN-2 on A549 and A549/DDP cells. | Cell Death & Disease

Fig. 7: The potential regulatory mechanism of inhibiting autophagy to enhance the cytotoxicity of FIIN-2 on A549 and A549/DDP cells.

From: Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma

Fig. 7

FIIN-2 can inhibit proliferation and induce mitochondria-mediated apoptosis in A549 and A549/DDP cells by inhibiting FRS2 and its downstream AKT and ERK pathways. FIIN-2 can also induce protective autophagy by mTOR inhibition and further activation of the class III PI3K pathway (Vps34-Beclin-1 complex). Moreover, cotreatment of FIIN-2 with the early stage or late-stage autophagy inhibitors 3-MA or CQ enhanced the cytotoxicity of FIIN-2 by inhibiting proliferation and inducing apoptosis in A549 and A549/DDP cells.

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