Table 2 Univariate and multivariate analysis for associations of SMYD3 protein expression with PFS in DLBCLs.

From: SMYD3 promotes aerobic glycolysis in diffuse large B-cell lymphoma via H3K4me3-mediated PKM2 transcription

Variables

Univariate analysis

Multivariate analysis

HR

95%CI

P-value

HR

95%CI

P-value

SMYD3

 Low

1 [Reference]

1 [Reference]

 High

2.184

1.369–3.486

0.001*

1.728

1.070–2.791

0.025*

Age

 ≤60

1 [Reference]

 

 >60

1.016

0.634–1.629

0.947

   

Sex

 Male

1 [Reference]

 

 Female

1.340

0.833–2.155

0.228

   

Primary site

 Nodal

1 [Reference]

   

 Extranodal

1.321

0.810–2.153

0.264

   

Ann Arbor Stage

 I–II

1 [Reference]

1 [Reference]

 III–IV

2.725

1.712–4.336

<0.001*

1.942

1.186–3.180

0.008*

IPI scores

 Low (0–2)

1 [Reference]

1 [Reference]

 High (3–5)

3.661

2.217–6.045

<0.001*

1.541

0.807–2.941

0.190

B symptoms

 No

1 [Reference]

1 [Reference]

 Yes

1.912

1.196–3.058

0.007*

1.773

1.088–2.887

0.021*

Serum LDH

 ≤240

1 [Reference]

1 [Reference]

 >240

3.230

2.014–5.083

<0.001*

2.365

1.388–4.031

0.002*

Type (IHC)

 GCB

1 [Reference]

 

 Non-GCB

0.743

0.469–1.178

0.207

   
  1. DLBCL Diffuse large B-cell lymphoma, GCB Germinal center B cell, IHC Immunohistochemistry, IPI International Prognostic Index, LDH Lactate dehydrogenase, CI Confidence interval, HR Hazard’s ratio.
  2. *P values are significant at P < 0.05.
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