Fig. 4: Expansion of PDGFRA+ non-myogenic mesenchymal cells in FSHD muscles. | Cell Death & Disease

Fig. 4: Expansion of PDGFRA+ non-myogenic mesenchymal cells in FSHD muscles.

From: Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients

Fig. 4

A Immunofluorescence staining for laminin (red), non-myogenic mesenchymal cells with PDGFRA (green) and nuclei with DAPI (blue). ×20 magnification. On the right, there are two enlarged representative areas showing PDGFRA+ cells for each experimental group. B The number of PDGFRA+ cells/field was reported as mean ± SD for each group. The ratio between the number of PDGFRA+ cells and the number of myofibers per field was assessed considering only the MRI parameter on STIR sequences (C) or also the T1 MRI value (D). The results were reported as mean ± SD. For all the analysis p-values were assessed by one-way ANOVA followed by Kruskal–Wallis multiple comparisons post hoc test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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