Fig. 4: Histological and TEM analyses of retinal structures in Mdm1+/+ and Mdm1−/− mice. | Cell Death & Disease

Fig. 4: Histological and TEM analyses of retinal structures in Mdm1+/+ and Mdm1−/− mice.

From: Mdm1 ablation results in retinal degeneration by specific intraflagellar transport defects of photoreceptor cells

Fig. 4

a Representative images of hematoxylin and eosin (H&E) stained retinal sections of Mdm1+/+ or Mdm1−/− mice at the indicated ages. Scale bar, 50 μm. Quantification of retinal thickness of Mdm1+/+ and Mdm1−/− mice with increasing age (b–d) (n = 15, 10, and 27 mice in Mdm1+/+, Mdm1+/−, and Mdm1−/− mice, respectively). b Total retinal thickness. c ONL thickness. d INL thickness. e TEM images of the retinas in female Mdm1+/+ or Mdm1−/− mice of the indicated ages. Scale bar, 10 μm. f Ultrastructural analysis of the retinas in Mdm1+/+ or Mdm1−/− mice at the indicated ages. Scale bar, 2 μm. GC, ganglion cell; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS, inner segment; OS, outer segment; RPE, retinal pigment epithelium; CC, connecting cilium. Statistical analysis, linear regression.

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