Fig. 6: circ_CEA downregulation suppresses lung metastasis of GC in vivo. | Cell Death & Disease

Fig. 6: circ_CEA downregulation suppresses lung metastasis of GC in vivo.

From: Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer

Fig. 6

A The photos of mouse lungs. After tail vein injection of AGS cells, BALB/c nude mice were randomly divided into four groups, and administrated with siNC (control group), circ_CEA simix, Dox +siNC (Dox group), and circ_CEA simix + Dox, respectively. B the representative images of lung metastatic focuses (HE staining, upper). The metastatic focuses were quantified (lower). *P < 0.05 vs control group, #P < 0.05 vs circ_CEA simix group, &P < 0.05 vs Dox group. C The body weights of the mice were measured twice a week. *P < 0.05 vs control group; #P < 0.05 vs circ_CEA simix group. D The speculated mechanism underlying the inhibitory effect of circ_CEA on stress-induced apoptosis in GC.

Back to article page