Fig. 1: PAF1 co-expressed with YAP1 in human PanINs and PDAC samples but not in normal pancreas.
From: PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer
A Immunohistochemical analysis of PAF1 and YAP1 in PDAC progression tissue samples. The green arrowhead in the magnified region of the normal pancreas points to the duct cell with no or low PAF1 staining, while the pink arrowhead in the magnified region points to the acinar cell with PAF1 staining. On the other hand, the red color arrowhead in the magnified region of the normal pancreas points to the duct cell with YAP1 staining, while the blue color arrowhead points to the acinar cell with no YAP1 staining. In addition, the yellow color arrowhead in chronic pancreatitis tissue samples points to the metaplastic ducts with PAF1 and YAP1 co-expression. Images were captured at ×20 magnification. B A histoscore was calculated by multiplying intensity and positivity. Data represent mean ± SD. p-values were calculated using ordinary one-way ANOVA (multiple comparisons). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. C, D Immunofluorescence images of human PDAC tissues stained with PAF1, YAP1, TEAD4, TEAD1, and DAPI. Scale bar 50 µm.
