Fig. 3: Pontin increases GBM cell migration, invasion and tumorigenic potential. | Cell Death & Disease

Fig. 3: Pontin increases GBM cell migration, invasion and tumorigenic potential.

From: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Fig. 3

a Representative images of transwell migration and invasion (left) and the comparison results (right). Data are expressed as means ± SDs, n = 3. **P < 0.01, ***P < 0.001 by one-way ANOVA (Dunnett’s post test). b Representative bioluminescent images revealing the xenografts in mice brain formed by indicated U87MG cells. c Quantification of the bioluminescence data monitored at Day 7, 14, 21 and 28 after transplantation. Data are expressed as means ± SDs, n = 5. ***P < 0.001 by one-way ANOVA (Dunnett’s post test). d Representative H&E staining images of the indicated xenografts. Red dotted lines labeled the junctions between xenografts and surrounding non-tumoral brain tissues. Invasion distances was indicated by red double-sided arrows. Scale bar, 50 μm (×100). e Survival curve of the tumour-bearing mice.

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