Fig. 4: Global profiles of Pontin-regulated differential gene expression and cellular signalling in GBM cells. | Cell Death & Disease

Fig. 4: Global profiles of Pontin-regulated differential gene expression and cellular signalling in GBM cells.

From: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Fig. 4

a Differential expressed coding genes affected by Pontin knockdown screened by RNA-seq (FC > 2, FDR < 0.05) were used to make the Volcano plot. b Downregulated genes incorporated in a were analyzed using STRING to plot the protein-protein association network with respective function annotation. c GSEA plots suggested a prominent correlation between Pontin and cellular signalling. d qRT-PCR confirmation of Pontin-regulated expression of genes involved in several biological processes or cellular signalling in indicated U87MG cells. Data are expressed as means ± SDs, n = 3.

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