Fig. 6: Downregulation of survivin and upregulation of DR5 contribute to ML323-mediated TRAIL sensitization. | Cell Death & Disease

Fig. 6: Downregulation of survivin and upregulation of DR5 contribute to ML323-mediated TRAIL sensitization.

From: Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5

Fig. 6

Caki-1 and HCT116 cells were transfected with vector and flag-survivin (A) or control siRNA or DR5 siRNA (B) followed by 30 μM ML323, 50 ng/mL TRAIL, or combination for 24 h. The sub-G1 population and protein expression were determined using flow cytometry and western blotting, respectively (A, B). Values in the graphs (A, B) represent the mean ± SD of three independent experiments. *P < 0.01 compared to combination of ML323 and TRAIL in vector. #P < 0.01 compared to combination of ML323 and TRAIL-treated control siRNA-transfected group.

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