Fig. 1: CircRNF144B was increased in OC tissues and predicted poor outcome. | Cell Death & Disease

Fig. 1: CircRNF144B was increased in OC tissues and predicted poor outcome.

From: CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1

Fig. 1

A OC tissues in the TCGA database were clustered into high autophagy signature and low autophagy signature groups according to their autophagy signature score. B The overall survival rate of patients with OC in the high autophagy signature and low autophagy signature groups. C Flow chart of key autophagy-associated circRNAs screening in OC. D Tissue fluorescence indicated the LC3 dots in OC tissues. Scale bar, 25 μm. E Heatmap indicated the upregulated and downregulated circRNAs between OC tissues with high LC dots and low LC3 dots. F Volcano plot indicated the gene change between OC tissues with high LC dots and low LC3 dots. G qRT-PCR was used to detect the expression of top 10 upregulated-circRNAs in OC tissues with high LC3 dots and low LC3 dots. H qRT-PCR was used to detect the expression of circRNF144B in OC tissues and adjacent tissues. I Differential expression of circRNF144B between OC tissues and adjacent tissues in patients based on the results detected by qRT-PCR. J Survival rate between patients with high and low circRNF144B expression. K qRT-PCR was used to detect the expression of circRNF144B in OC cells (A2780, HEY-T30, SKOV3, OVCAR-3, ES2, and OV-1063) and normal ovarian epithelial cell line IOSE80. *, P < 0.05; ***, P < 0.001.

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