Fig. 6: Effects of circRNF144B was dependent on miR-342-3p/FBXL11 axis. | Cell Death & Disease

Fig. 6: Effects of circRNF144B was dependent on miR-342-3p/FBXL11 axis.

From: CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1

Fig. 6

MiR-342-3p was overexpressed, and FBXL11 was suppressed in SKOV3 and OVCAR-3 cells. A The CCK-8 assay was used to detect cell viability in each group. B Colony formation assay was used to detect colony formation in each group. C EDU positive rate in each group was detected. Scale bar, 100 μm. D Wound healing assay was used to detect cell migration in each group. Scale bar, 50 μm. E Transwell assay was used to detect cell invasion in each group. Scale bar, 50 μm. F Western blotting was used to detect LC3 and P62 in each group. G Confocal microscopy was used to detect the number of autophagosomes and autophagolysosomes in each group. Scale bar, 25 μm. *, P < 0.05; **, P < 0.01.

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