Fig. 7: FBXL11 increased the ubiquitination of Beclin-1 in OC cells. | Cell Death & Disease

Fig. 7: FBXL11 increased the ubiquitination of Beclin-1 in OC cells.

From: CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1

Fig. 7

A Silver staining indicated protein binding with FBXL11. B Top 4 interacting proteins with FBXL11 are shown. C The secondary mass spectrograms indicated BECN1 binding with FBXL11. D Endogenic immunoprecipitation indicated the binding between FBXL11 and Beclin-1. E Ectogenic immunoprecipitation indicated the binding between FBXL11 and Beclin-1. F CHX was used to inhibit protein synthesis, and degradation of Beclin-1 was detected in SKOV3 and OVCAR-3 cells with FBXL11 knockdown and control. G The ubiquitination level of Beclin-1 in SKOV3 and OVCAR-3 cells with FBXL11 knockdown and control was detected.

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