Fig. 1: Prostate cancer progression is associated with increased CSF1 concentration and Nitric oxide synthases.
From: S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer
The relative expression of CSF1 and NOS3 was studied using RNA sequencing data for Prostate adenocarcinoma from The Cancer Genome Atlas (TCGA). A Graphs showing expression of CSF1 and NOS3 across different Gleason Grades. B Quantification of CSF1 and C NOS3 was done by enzyme-linked immunosorbent assay (ELISA) performed in PBMCs collected from different patient blood samples with different Gleason grades (n = 2). CSF1 levels are expressed as pg/ml, while NOS3 levels are expressed as ng/ml. D Western blot following immuno-precipitation of Peripheral Blood Mononuclear Cells (PBMCs) showing the expression of NOS3 (NOS3) (n = 2). E Immunofluorescent staining images showing expression of NOS3 (green) in patient biopsies from Gleason Grade 6 and 9. Data are means ± SEM. n, number of samples. GS, Gleason grade. *p < 0.05; **p < 0.01; ***p < 0.001.
