Table 2 Univariate and multivariate analysis of factors associated with overall survival in GC patients.

From: Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer

 

Overall survival

 
 

HR (95% CI)

P value

Univariate analysis

  

 Age (≤60 years vs. >60 years)

1.32 (0.97–1.80)

0.082

 Sex (male vs. female)

0.72 (0.47–1.10)

0.130

 Tumor diameter (≤5 cm vs. >5 cm)

2.31 (1.71–3.12)

<0.001

 Surgical type (subtotal gastrectomy vs. total gastrectomy)

2.07 (1.50–2.85)

<0.001

 Tumor differentiation (poor vs. well/moderate)

0.44 (0.31–0.61)

<0.001

 pT stage (T1–3 vs. T4)

3.39 (2.44–4.69)

<0.001

 pN stage (N0 vs. N+)

7.15 (4.64–11.02)

<0.001

 pTNM stage (I–II vs. III)

7.75 (5.31–11.30)

<0.001

 Lymphovascular invasion (present vs. absent)

0.43 (0.31–0.60)

<0.001

 CRABP2 expression (negative vs. positive)

1.57 (1.16–2.11)

0.003

Multivariate analysis

  

 Age (≤60 years vs. >60 years)

1.24 (0.9–1.7)

0.190

 Sex (male vs. female)

0.66 (0.43–1.02)

0.059

 Tumor diameter (≤5 cm vs. >5 cm)

1.11 (0.79–1.55)

0.545

 Surgical type (subtotal gastrectomy vs. total gastrectomy)

1.23 (0.9–1.68)

0.198

 Tumor differentiation (poor vs. well/moderate)

0.9 (0.63–1.28)

0.545

 pT stage (T1–3 vs. T4)

1.02 (0.68–1.52)

0.936

 pN stage (N0 vs. N+)

1.98 (0.94–4.19)

0.073

 pTNM stage (I–II vs. III)

3.71 (1.77–7.8)

0.001

 Lymphovascular invasion (present vs. absent)

0.72 (0.51–1.01)

0.054

 CRABP2 expression (negative vs. positive)

1.41 (1.01–1.98)

0.043

  1. All P values < 0.05 are indicated in bold print.