Fig. 2: Identification of lineage-selective SEs and functional enrichment of their target. | Cell Death & Disease

Fig. 2: Identification of lineage-selective SEs and functional enrichment of their target.

From: Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells

Fig. 2

A Scatter plots show the mean rank of adipocytes- (left panel) and osteoblasts-selective SEs (right panel) in three cell types, the same genome region in three cell types were connected by lines, some examples were marked with dark gray, the target genes of these examples were also showed. B Bar plot shows the counts of lineage-selective SEs which with a signal rank ≤1700 in hMSCs. C The H3K27ac signal profile of lineage-selective SEs in three cell types. All SE regions were extended to a consistent length and the surrounding 3 kb regions were also plotted in figures. D Violin plots show expression of adipocytes-selective SEs (left panel) and osteoblasts-selective SEs (right panel) in three cell types and the statistical difference among them; ***P < 0.001, ns: not significant. E Bar plot of significant enriched (P ≤ 0.05) GO and KEGG terms of genes regulated by adipocytes- or osteoblasts-selective SEs. The dashed line corresponding to the significance threshold. F, G Genome browser plots show examples of adipocytes-selective SE (F) and osteoblasts-selective SE (G) with their targets. Dashed line indicates the position of TSS of target genes. The arc with arrow links the functional region within SEs and TSS of target gene, which was predicted by ABC model.

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