Fig. 5: Lineage-selective SEs mediated the formation of CRC. | Cell Death & Disease

Fig. 5: Lineage-selective SEs mediated the formation of CRC.

From: Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells

Fig. 5

A Table depicts TFs binding motifs that specifically enriched in functional regions of adipocytes- or osteoblasts-selective SEs and corresponding q-values. B Bar plots display the number of lineage-selective SEs bound by a specific number of TFs. C Bar plots display the number of target genes of lineage-selective SEs regulated by a specific number of TFs. D In silico predicted CRC constituted by TFs regulated by lineage-selective SEs. E–G RT-qPCR analysis of gene expression between control and target gene knockdown cells. GAPDH was used as loading control. *P < 0.05, **P < 0.01, ***P < 0.001. H, I Bar plot of ChIP-qPCR result displays the MEF2A binding efficiency at osteoblasts-selective SEs of MEF2A and ETS1/FLI1. **P < 0.01. J, K Bar plot of ChIP-qPCR result displays the ETS1 binding efficiency at osteoblasts-selective SEs of ETS1/FLI1 and MEF2A. ***P < 0.001.

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