Fig. 5: Bhlha15 binds to the promoter of Atp8b1 in acinar cells. | Cell Death & Disease

Fig. 5: Bhlha15 binds to the promoter of Atp8b1 in acinar cells.

From: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Fig. 5

A Signal tracks showing the open chromatin region in the Atp8b1 promoter, as determined by ATAC-seq, in Group A and B. The differential peaks in the two groups are shown above the tracks. The binding and co-occupancy of H3K27me3 and mRNA-seq signals of genes in pancreatic acinar cells from Groups A and B w ere visualized with Integrative Genomics Viewer. B Heatmap shown 11 genes were identified by predicting the binding sites of transcription factor to the open chromatin regions around the TSS of Atp8b1 using Jaspar (threshold score, > 80). The mRNA (C) and protein (D) expression levels of Bhlha15 in pancreatic tissue were determined by quantitative RT–PCR and western blotting, respectively. ***p ≤ 0.001.

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