Fig. 7: Graphical abstract. | Cell Death & Disease

Fig. 7: Graphical abstract.

From: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Fig. 7

Mechanistic diagram showing how efferocytosis effect CP process through regulating Bhlha15/Atp8b1/LPC pathway to alter the regulation of phospholipid metabolism. Under normal conditions on the left, macrophages engulf apoptotic acinar cells through efferocytosis to resolve inflammation. Alcohol abuse and cholelithiasis can injury pancreas and impaire the efficiency of efferocytosis. Impaired efferocytosis decreases the efficiency of apoptotic cell clearance. H3K27me3 of histones suppresses Atp8b1 transcription, and decrease LPC concentration. This reduction means that less LPC is available to interact with G2A and fewer macrophages are attracted to engulf apoptotic cells, leading to further inflammation.

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