Fig. 4: Identification of specific marker genes correlated with MF/SS disease progression.
From: Single-cell analyses reveal novel molecular signatures and pathogenesis in cutaneous T cell lymphoma
A Heatmap of significantly DEGs in each subset of malignant and benign CD4+ T cells from PBMCs. B Heatmap of significantly DEGs in each subset of malignant and benign lymphocytes from skin tissues. C Venn diagram showing overlap of significantly upregulated expressed genes of blood- and skin-derived malignant CD4+ T cells. D t-SNE visualization of scRNA-seq data from PBMC CD4+ T cells in the SS patient. E RNA velocity analysis of PBMC CD4+ T cells in the SS patient. F Violin plots showed the expression of TOX, DNM3, KLHL42, HACD1, PGM2L1, and SESN3 in each cluster. G Immunohistochemical stain of TOX, DNM3, KLHL42, PGM2L1, and SESN3 in skin biopsies of HC, PE patient, early-stage MF patients, advanced-stage MF patients and SS patients, each at 200× (left) and 400× (right). H Correlation analysis of disease stage with IHC scores of TOX, DNM3, KLHL42, PGM2L1, and SESN3 in MF/SS. Pearson’s correlation coefficient.
